TMEM30A
Description
The TMEM30A (transmembrane protein 30A) is a protein-coding gene located on chromosome 6.
TMEM30A is an essential component of the P4-ATPase flippase complex, which plays a crucial role in maintaining the asymmetric distribution of phospholipids across various membranes. This complex utilizes ATP hydrolysis to transport aminophospholipids from the outer leaflet to the inner leaflet of membranes. Phospholipid translocation, facilitated by TMEM30A, is implicated in vesicle formation and the uptake of lipid signaling molecules. TMEM30A is specifically required for the proper folding, assembly, and ER-to-Golgi transport of the ATP8A2:TMEM30A flippase complex. This complex is linked to the regulation of neurite outgrowth and primarily transports phosphatidylserine (PS) and phosphatidylethanolamine (PE) when reconstituted into liposomes. The ATP8A1:TMEM30A flippase complex, also involving TMEM30A, appears to regulate cell migration potentially through the flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. TMEM30A is essential for the formation of intermediate phosphoenzymes for ATP8A2, ATP8B1, and ATP8B2 P-type ATPases. TMEM30A facilitates the uptake of platelet-activating factor (PAF), the synthetic drug alkylphospholipid edelfosine, and likely perifosine in association with ATP8B1. Additionally, TMEM30A mediates the export of various alpha subunits (ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B, and ATP11C) from the ER to other membrane locations.
TMEM30A is also known as C6orf67, CDC50A.
