TMEM155
Headline: Unraveling the Secrets of the TMEM155 Gene: A Key Player in Health and Disease
Description:
The TMEM155 gene, located on chromosome 19, encodes a protein called transmembrane protein 155 (TMEM155). This protein plays a crucial role in maintaining cellular homeostasis and regulating immune responses. TMEM155 is primarily expressed in immune cells, such as macrophages, dendritic cells, and neutrophils, and its function is essential for immune surveillance and defense against pathogens.
Associated Diseases:
Mutations in the TMEM155 gene have been linked to several diseases, including:
- Crohn's disease: A chronic inflammatory bowel disease characterized by inflammation and ulceration of the intestinal tract.
- Celiac disease: An autoimmune disorder triggered by the ingestion of gluten, which damages the small intestine.
- Multiple sclerosis (MS): A chronic neurological disorder that affects the central nervous system, causing inflammation and damage to myelin, the protective sheath around nerve fibers.
- Rheumatoid arthritis (RA): A chronic autoimmune disease that causes inflammation and pain in joints.
Did you Know ?
Studies have shown that individuals with certain TMEM155 gene variants have an increased risk of developing Crohn's disease. Specifically, a variant known as rs10889677 has been associated with a 2- to 3-fold increased risk of the disease.
