TMEM132A
Description
The TMEM132A (transmembrane protein 132A) is a protein-coding gene located on chromosome 11.
TMEM132A might contribute to brain development during embryonic and postnatal stages. It enhances resistance to cell death when cells are deprived of nutrients in laboratory settings. Furthermore, it appears to control the expression of the GFAP gene (which encodes a protein involved in maintaining the structural integrity of brain cells) in response to cAMP signaling through a pathway involving STAT3 phosphorylation.
TMEM132A is also known as GBP, HSPA5BP1.
Associated Diseases
- melorheostosis
- brachydactyly type A7
- symphalangism with multiple anomalies of hands and feet
- Acropectorovertebral dysplasia
- synpolydactyly type 1
- ulnar hemimelia
- syndactyly type 4
- lethal occipital encephalocele-skeletal dysplasia syndrome
- mesoaxial synostotic syndactyly with phalangeal reduction
- glioblastoma
- colorectal cancer
- cancer
