TMBIM4
Description
The TMBIM4 (transmembrane BAX inhibitor motif containing 4) is a protein-coding gene located on chromosome 12.
TMBIM4 (Transmembrane BAX inhibitor motif-containing protein 4) is a protein encoded by the TMBIM4 gene in humans. It is also known as human Golgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization. TMBIM4 is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca+2, an increase of TMBIM4 can help prevent apoptosis. TMBIM4 is also involved in promoting cell migration and has been identified as a novel Golgi cation channel. Other GAAPs can be found in all eukaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.
TMBIM4 is an anti-apoptotic protein that can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. It can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.
TMBIM4 is also known as CGI-119, GAAP, LFG4, S1R, ZPRO.
