TLX2

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Description

The TLX2 (T cell leukemia homeobox 2) is a protein-coding gene located on chromosome 2.

TLX2 is a protein encoded by the TLX2 gene in humans.

TLX2 is a transcription activator that binds to DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. It binds DNA through its homeobox domain. TLX2 is essential for normal cell death of enteric neurons in the gastrointestinal tract. It is also crucial for the normal development of the enteric nervous system and for the proper development of normal motility in the gastrointestinal tract.

TLX2 is also known as HOX11L1, NCX.

Associated Diseases

• Hirschsprung disease
• cancer
• atresia of small intestine
• microvillus inclusion disease
• chronic diarrhea due to glucoamylase deficiency
• inflammatory bowel disease 30
• bile acid malabsorption, primary, 1
• volvulus of midgut
• congenital short bowel syndrome
• visceral neuropathy, familial, 1, autosomal recessive
• visceral myopathy 1
• familial visceral myopathy
• colonic atresia
• NK-cell enteropathy
• congenital sucrase-isomaltase deficiency
• palmoplantar keratoderma-esophageal carcinoma syndrome