TLR1

Description

The TLR1 (toll like receptor 1) is a protein-coding gene located on chromosome 4.

TLR1, a member of the Toll-like receptor (TLR) family, is a crucial component of the innate immune system. It recognizes bacterial lipoproteins and glycolipids in complex with TLR2. TLR1 is a cell surface receptor encoded by the TLR1 gene located on chromosome 4. Binding of ligands to TLR1 activates intracellular signaling cascades, triggering an inflammatory response and initiating immune processes. TLR1 cooperates with TLR2 in recognizing bacterial triacyl lipoproteins and has been shown to recognize the outer surface lipoprotein of Borrelia burgdorferi. TLR1-deficient mice demonstrate its importance in recognizing triacyl lipopeptides. TLR1, along with other Toll-like receptors, plays a vital role in managing the gut microbiota and detecting pathogens in the epithelial cell layer lining the small and large intestine. TLR1 is synthesized in the endoplasmic reticulum.

TLR1 plays a crucial role in the innate immune response to microbial agents, particularly recognizing diacylated and triacylated lipopeptides. It collaborates with TLR2 to mediate the immune response to bacterial lipoproteins or lipopeptides. Upon encountering triacylated lipopeptides, TLR1 forms an activation cluster with TLR2 and CD14. This cluster triggers signaling from the cell surface and is subsequently transported to the Golgi apparatus via a lipid-raft dependent pathway. TLR1 further activates the downstream signaling pathway involving MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response.

TLR1 is also known as CD281, TIL, TIL. LPRS5, rsc786.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing