TLDC1
Unlocking the Secrets of the tldc1 Gene: An In-Depth Analysis
Description
The tldc1 gene, located on chromosome 6, encodes a protein called translocated in liposarcoma 1. This protein is crucial for regulating cell growth and division, particularly in the formation of blood vessels. Mutations in the tldc1 gene have been linked to a variety of diseases, including cancer and vascular disorders.
Associated Diseases
- Liposarcoma: A type of cancer that develops in fat cells, often in the thigh or abdomen. Mutations in tldc1 are commonly found in well-differentiated and dedifferentiated liposarcomas.
- Angiosarcoma: A rare and aggressive type of cancer that originates in the blood vessels. tldc1 mutations have been identified in approximately 10% of angiosarcomas.
- Kaposi's Sarcoma: A type of cancer that causes lesions on the skin and internal organs, often associated with human immunodeficiency virus (HIV) infection. tldc1 mutations have been implicated in some cases of Kaposi's sarcoma.
- Lymphatic Malformations: A congenital condition characterized by abnormal development of lymph vessels, leading to fluid-filled cysts and swelling. Mutations in tldc1 have been found in approximately 50% of lymphatic malformations.
Did you Know ?
- Mutations in the tldc1 gene are responsible for approximately 20-30% of liposarcomas, making it one of the most common genetic alterations in this type of cancer.
