TFIP11
Description
The TFIP11 (tuftelin interacting protein 11) is a protein-coding gene located on chromosome 22.
Tuftelin-interacting protein 11 is a protein that in humans is encoded by the TFIP11 gene.
TFIP11 plays a crucial role in pre-mRNA splicing, specifically during the late stages of spliceosome disassembly. It facilitates the transition from the Intron Large (IL) complex, containing U2, U5, and U6 snRNPs, to the snRNP-free Intron Small (IS) complex. This transition is mediated by TFIP11's interaction with DHX15, leading to efficient debranching and turnover of excised introns. TFIP11 may also contribute to the differentiation of ameloblasts and odontoblasts, and the formation of the enamel extracellular matrix.
TFIP11 is also known as NTR1, STIP, STIP-1, Spp382, TIP39, bK445C9.6.
