TEX264
Description
The TEX264 (testis expressed 264, ER-phagy receptor) is a protein-coding gene located on chromosome 3.
TEX264, also known as Putative secreted protein Zsig11, is a protein involved in the removal of damaged portions of the endoplasmic reticulum (ER) through autophagy and the repair of DNA damage. It plays a critical role in the formation of autophagosomes, the structures responsible for engulfing and degrading damaged ER segments, and interacts with various proteins, including ATG8 family members and VCP/p97, to facilitate these processes.
TEX264 is a major receptor for reticulophagy (ER-phagy), a process that removes damaged portions of the endoplasmic reticulum (ER). It acts independently of other known receptors to remodel the ER into autophagosomes, which then fuse with lysosomes for ER turnover. This process is triggered by nutrient stress. TEX264 binds to ATG8 proteins, including MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1, through a LIR motif, and plays a crucial role in the formation of the autophagosome by capturing ER segments and directing their engulfment. TEX264 also contributes to the repair of DNA damage. It interacts with VCP/p97, a protein involved in protein degradation, and facilitates the resolution of covalent DNA-protein cross-links (DPCs) during DNA synthesis by bridging VCP/p97 to DPCs and initiating the action of SPRTN, an enzyme that resolves DPCs.
TEX264 is also known as ZSIG11.
