TEX12

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Description

The TEX12 (testis expressed 12) is a protein-coding gene located on chromosome 11.

TEX12 is a protein that forms part of the transverse central element of synaptonemal complexes (SCSs). SCSs are structures that form between homologous chromosomes during the first stage of meiosis (meiotic prophase), helping to align the chromosomes correctly for division. TEX12's incorporation into the central element of the SCS requires the presence of another protein called SYCP1.

TEX12 is also known as -.

Associated Diseases

• cancer
• male infertility with teratozoospermia due to single gene mutation
• partial chromosome Y deletion
• 46,XX testicular disorder of sex development
• spermatogenic failures 50
• spermatogenic failure 25
• congenital bilateral absence of vas deferens
• spermatogenic failure 73
• spermatogenic failure 74
• spermatogenic failure 61
• isochromosomy Yp
• spermatogenic failure 48
• 46,XY complete gonadal dysgenesis
• spermatogenic failure, X-linked, 2