TEN1-CDK3
Description
The TEN1-CDK3 (TEN1-CDK3 readthrough (NMD candidate)) is a ncRNA gene located on chromosome 17.
The TEN1-CDK3 complex is a heterodimer composed of the TEN1 protein and the cyclin-dependent kinase 3 (CDK3). TEN1 serves as a scaffolding protein, facilitating the interaction between CDK3 and its substrates, including the retinoblastoma protein (Rb). This interaction is essential for the phosphorylation of Rb, a key event in the regulation of cell cycle progression. Moreover, the TEN1-CDK3 complex participates in the control of DNA replication and repair processes.
The TEN1-CDK3 complex plays a crucial role in regulating the activity of the cyclin-dependent kinase 3 (CDK3). TEN1 acts as a scaffold protein, bringing together CDK3 and its substrates, such as the retinoblastoma protein (Rb). This interaction leads to the phosphorylation of Rb, which in turn promotes cell cycle progression. The complex also contributes to the regulation of DNA replication and repair processes.
TEN1-CDK3 is also known as C17orf106, C17orf106-CDK3, TEN1.
