Telangiectasia Macularis Eruptiva Perstans (TMEP)
Description
Telangiectasia Macularis Eruptiva Perstans (TMEP), also known as "persistent eruptive macular telangiectasia" or "cherry red spots", is a rare skin condition characterized by the appearance of numerous small, red, persistent spots (telangiectasias) on the skin. These spots are typically located on the trunk, arms, and legs and may be accompanied by other symptoms like itching or burning. While the exact cause of TMEP is unknown, several factors, including genetic predisposition and environmental triggers, are believed to play a role. Understanding the signs, symptoms, and management options for TMEP is crucial for individuals affected by this condition. This blog aims to provide comprehensive information about TMEP, helping you navigate the journey towards effective management and a better understanding of this rare skin condition.
Genes Involved
Genes Involved:
- RASA1: This gene provides instructions for making a protein involved in cell signaling pathways. Mutations in RASA1 are associated with a higher risk of developing TMEP.
- PTPN11: This gene plays a role in the development and function of the immune system. Mutations in PTPN11 have been linked to various conditions, including Noonan syndrome, which can sometimes be associated with TMEP.
Recognizing the Signs and Symptoms
Recognizing the Signs and Symptoms:
- Characteristic red spots: The most prominent feature of TMEP is the presence of numerous small, red, persistent spots on the skin, typically measuring 1-5 mm in diameter. These spots are often described as "cherry red" in appearance.
- Location: The spots usually appear on the trunk, arms, and legs, but they can also occur on the face, neck, and scalp.
- Number: The number of spots can vary widely from person to person, ranging from a few to hundreds or even thousands.
- Other symptoms: Some individuals with TMEP may experience itching, burning, or a feeling of warmth in the affected areas. In rare cases, TMEP may be associated with other conditions, such as connective tissue disorders or autoimmune diseases.
Causes
Causes:
While the exact cause of TMEP is unknown, several factors are believed to play a role, including:
- Genetic predisposition: Individuals with a family history of TMEP are at an increased risk of developing the condition.
- Environmental triggers: Certain environmental factors, such as sun exposure, trauma, or infections, may trigger the onset of TMEP.
- Immune system dysregulation: Some researchers suggest that TMEP may be caused by an overactive immune system response, leading to inflammation and the development of telangiectasias.
- Underlying medical conditions: In rare cases, TMEP may be associated with other conditions, such as connective tissue disorders or autoimmune diseases.
Inheritance/recurrence risk
Inheritance or Recurrence Risk:
The inheritance pattern of TMEP is not fully understood. While some cases may be familial, others seem to occur sporadically. However, a genetic predisposition is believed to play a role in the development of TMEP. If a family member has TMEP, the risk of developing the condition in other family members may be higher.
