TDRD5
Description
The TDRD5 (tudor domain containing 5) is a protein-coding gene located on chromosome 1.
TDRD5 plays a crucial role in suppressing transposable elements during spermatogenesis, preventing their activation and safeguarding the integrity of the germline. It likely functions through the piRNA pathway, which involves complexes of piRNAs and Piwi proteins that regulate the methylation and repression of transposons. TDRD5 is also essential for the formation of chromatoid bodies (CBs).
TDRD5 is also known as TUDOR3.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 61
- spermatogenic failures 50
- spermatogenic failure 48
- spermatogenic failure 26
- spermatogenic failure 31
- spermatogenic failure 20
- spermatogenic failure 25
- spermatogenic failure 5
- spermatogenic failure 23
- spermatogenic failure 52
- spermatogenic failure 19
- spermatogenic failure 45
- spermatogenic failure 49
- spermatogenic failure 43
