TDO2
Description
The TDO2 (tryptophan 2,3-dioxygenase) is a protein-coding gene located on chromosome 4.
TDO2 is the human gene that encodes the enzyme tryptophan 2,3-dioxygenase (TDO). TDO is a heme-containing enzyme that catalyzes the first and rate-limiting step in the kynurenine pathway, the breakdown of tryptophan. This pathway is essential for the regulation of tryptophan levels in the body. TDO is primarily found in the liver, but can also be expressed in other tissues, such as the brain and epididymis. The enzyme is typically tetrameric, with each subunit containing one heme molecule. TDO was first discovered in the 1930s and has since been found in both eukaryotes and prokaryotes. The expression of TDO in mammals is normally restricted to the liver, but it can be induced in response to stimuli. The first recombinant expression of TDO was achieved using rat TDO in E. coli.
TDO2 encodes a heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring, converting L-tryptophan to N-formyl-L-kynurenine. This enzyme is responsible for the oxidative cleavage of the indole moiety.
TDO2 is also known as HYPTRP, TDO, TO, TPH2, TRPO.
