TCHP
Description
The TCHP (trichoplein keratin filament binding) is a protein-coding gene located on chromosome 12.
Trichoplein keratin filament-binding protein is a protein that in humans is encoded by the TCHP gene.
TCHP, also known as Trichoplein, is a tumor suppressor protein that inhibits cell growth and promotes apoptosis during cellular stress. It downregulates HSPB1 by inhibiting its phosphorylation, thereby inhibiting cell growth in bladder and prostate cancer cells. TCHP functions as a 'capping' or 'branching' protein for keratin filaments at the cell periphery, regulating K8/K18 filament and desmosome organization in simple epithelial cells. It acts as a negative regulator of ciliogenesis.
TCHP is also known as TpMs.
Associated Diseases
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- thyroid hormone metabolism, abnormal, 2
- sitosterolemia
- amelogenesis imperfecta
- dentin dysplasia type I
- homozygous familial hypercholesterolemia
- hypercholesterolemia, autosomal dominant, 3
