TCEA2
Description
The TCEA2 (transcription elongation factor A2) is a protein-coding gene located on chromosome 20.
TCEA2, a human gene, encodes a protein found in the nucleus that functions as an SII class transcription elongation factor. These factors help RNA polymerase II overcome obstacles during transcription, specifically at template-encoded arresting sites. TCEA2 interacts with the basal transcription factor IIB and has been shown to interact with MAGEA11. Two transcript variants encoding different isoforms have been found for this gene.
TCEA2 is crucial for efficient RNA polymerase II transcription elongation past DNA sequences that can temporarily halt the process. These arresting sites trap a portion of elongating RNA polymerases, leading to stalled transcription complexes. TCEA2's action involves cleaving the nascent transcript, allowing transcription to resume from the new 3'-terminus.
TCEA2 is also known as TFIIS.
