TCAIM
Description
The TCAIM (T cell activation inhibitor, mitochondrial) is a protein-coding gene located on chromosome 3.
TCAIM is a protein encoded by the TCAIM gene, located on chromosome 3. The gene is 71,333 bases long and encodes a 496 residue protein with a molecular weight of 57925 Da. TCAIM exists in four different isoforms and is highly conserved among species. The protein has an isoelectric point of 6.81, which is significantly higher than the average for human proteins. The gene contains 8 alternatively spliced exons, resulting in 4 transcript variants. The primary transcript is 3520 bp long and is well conserved among orthologs. The protein's tertiary structure has been predicted.
May play a role in regulating T-cell apoptosis.
TCAIM is also known as C3orf23, TOAG-1, TOAG1.
Associated Diseases
- bipolar disorder
- anorexia nervosa
- schizophrenia
- cholesterol-ester transfer protein deficiency
- neutropenia, severe congenital, 2, autosomal dominant
- X-linked severe congenital neutropenia
- hypertriglyceridemia 2
- 22q11.2 deletion syndrome
