TBL1X
Description
The TBL1X (transducin beta like 1 X-linked) is a protein-coding gene located on chromosome X.
TBL1X, also known as Transducin (beta)-like 1X-linked, is a protein encoded by the TBL1X gene in humans. It shares similarities with the WD40 repeat-containing protein family, known for their regulatory function. The WD40 repeats are believed to mediate protein-protein interactions, and members of this family are involved in various cellular processes like signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly, and potentially cytotypic differentiation. TBL1X is a subunit of the corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex, along with histone deacetylase 3 protein. The TBL1X gene is located near the ocular albinism gene and is suspected to play a role in the pathogenesis of ocular albinism with late-onset sensorineural deafness. TBL1X is highly similar to the Y chromosome TBL1Y gene. TBL1X interacts with GPS2, HDAC3, NCOA1, and NCOA2.
TBL1X is an F-box-like protein involved in recruiting the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. It plays a crucial role in the activation of transcription mediated by nuclear receptors. TBL1X is likely a component of corepressor complexes that mediate the recruitment of the 19S proteasome complex, leading to the degradation of transcription repressor complexes. This allows cofactor exchange and facilitates gene expression regulation.
TBL1X is also known as CHNG8, EBI, SMAP55, TBL1.
