TAS2R46

Description

The TAS2R46 (taste 2 receptor member 46) is a protein-coding gene located on chromosome 12.

TAS2R46 (Taste receptor type 2 member 46) is a protein involved in bitter taste perception. It belongs to the family of G-protein coupled receptors (GPCRs) and is related to class A-like GPCRs. There are 25 known T2Rs in humans responsible for bitter taste perception. The TAS2R46 gene is located on chromosome 12 within a cluster of taste receptor genes. It encodes a bitter receptor that is broadly tuned to sesquiterpene lactones, clerodane diterpenoids, labdane diterpenes, and more. The structure of TAS2R46 was solved in 2022 using cryo-EM. The structure can be downloaded from the Protein Data Bank. In addition to the oral cavity, TAS2R46 has been shown to be expressed in other tissues like human bone marrow stromal-derived cells (MSC) and vascular smooth muscle cells (VSMC). To date, 68 ligands for TAS2R46 have been identified, including some drugs. Two well-known ligands for TAS2R46 are Atropine and Strychnine.

TAS2R46 is also known as T2R46, T2R54.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing