TAS2R43
Description
The TAS2R43 (taste 2 receptor member 43) is a protein-coding gene located on chromosome 12.
Taste receptor type 2 member 43 is a protein encoded by the TAS2R43 gene in humans. It is involved in taste perception.
TAS2R43, a gustducin-coupled receptor, plays a role in detecting bitter compounds in the mouth and digestive tract. It activates signaling pathways involving PLCB2 and the calcium-regulated cation channel TRPM5. Interestingly, TAS2R43 is triggered by artificial sweeteners saccharin and acesulfame K. In airway cells, TAS2R43 binding to bitter compounds elevates intracellular calcium levels and increases ciliary beat frequency, suggesting a potential role in protecting the airways from harmful substances.
TAS2R43 is also known as T2R43, T2R52.
