TAS2R14
Description
The TAS2R14 (taste 2 receptor member 14) is a protein-coding gene located on chromosome 12.
TAS2R14, or Taste receptor type 2 member 14, is a protein encoded by the TAS2R14 gene in humans. It belongs to the G-protein coupled receptor family (GPCRs) specifically responsible for detecting bitter substances (T2Rs/TAS2Rs). There are 25 known T2Rs in humans, each responsible for recognizing various bitter compounds. TAS2R14 is one of these receptors, detecting a wide range of both natural and synthetic bitter molecules.
The TAS2R14 gene is located on chromosome 12p13, within a cluster of taste receptor genes. A close relative is the TAS2R13 gene.
Significant variations (SNPs) have been observed in taste receptors, including TAS2R14, and some of these variations directly affect the gene's function and expression. Data regarding these SNPs is available from the 1000 Genomes Project.
Site-directed mutagenesis studies have been conducted on TAS2R14, focusing on identifying specific residues critical for its function.
TAS2R14 is also known as T2R14, TRB1.
Associated Diseases
- schizophrenia 15
- Phelan-McDermid syndrome
- Potocki-Lupski syndrome
- Smith-Magenis syndrome
- intellectual developmental disorder, X-linked, syndromic, Pilorge type
- FRAXE intellectual disability
- cancer
