TARM1
Description
The TARM1 (T cell-interacting, activating receptor on myeloid cells 1) is a protein-coding gene located on chromosome 19.
TARM1 may function as a receptor. It plays a role in regulating immune responses by inhibiting the activation and proliferation of CD4+ T cells, likely through interaction with an unidentified ligand on the T cell surface. Additionally, TARM1 appears to enhance the production of pro-inflammatory cytokines in macrophages and neutrophils in response to Toll-like receptor activation.
TARM1 is also known as OLT-2.
Associated Diseases
- common variable immunodeficiency
- isolated agammaglobulinemia
- severe combined immunodeficiency due to CARD11 deficiency
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive
- immunodeficiency 18
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- immunodeficiency 72 with autoinflammation
- severe combined immunodeficiency due to CTPS1 deficiency
- immunodeficiency 62
- combined immunodeficiency with skin granulomas
- inborn error of immunity
- immunodeficiency 105
- immunodeficiency, common variable, 4
- autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- combined immunodeficiency due to moesin deficiency
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
- classic Hodgkin lymphoma