TARBP2
Description
The TARBP2 (TARBP2 subunit of RISC loading complex) is a protein-coding gene located on chromosome 12.
TARBP2 is a human protein encoded by the TARBP2 gene. It binds to the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing of the TARBP2 gene results in multiple transcript variants encoding different isoforms. TARBP2 has been shown to interact with Protein kinase R and RBM14.
TARBP2 is essential for the formation of the RNA-induced silencing complex (RISC). It is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which comprises DICER1, AGO2, and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are responsible for processing precursor miRNAs (pre-miRNAs) into mature miRNAs and subsequently loading them onto AGO2. The mature miRNA bound to AGO2 forms the minimal RISC, which can detach from DICER1 and TARBP2. TARBP2 might also participate in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. It binds to the 3'-UTR of PRM1 in vitro and potentially acts as a translation repressor. For certain pre-miRNA substrates, it may influence the cleavage site selection by DICER1. Moreover, TARBP2 negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting IRF7 phosphorylation and promoting its Lys48-linked ubiquitination and degradation.
TARBP2 is also known as LOQS, TRBP, TRBP1, TRBP2.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 48
- spermatogenic failure 25
- congenital bilateral absence of vas deferens
- spermatogenic failure 1
- spermatogenic failure, X-linked, 3
- spermatogenic failure 65
- spermatogenic failure 40
- spermatogenic failure 39
- spermatogenic failure 61
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 47
