TAF1B

Description

The TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B) is a protein-coding gene located on chromosome 2.

TAF1B (TATA box-binding protein-associated factor RNA polymerase I subunit B) is an enzyme produced by the TAF1B gene in humans. It's essential for the initiation of transcription by RNA polymerase I, a process that requires the formation of a complex containing TBP (TATA-binding protein) and three TAFs (TBP-associated factors) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes, positioning the polymerase correctly and acting as a conduit for regulatory signals. TAF1B is one of the SL1-specific TAFs. It has been shown to interact with RRN3.

TAF1B is part of the RNA polymerase I core factor complex, functioning as a GTF2B/TFIIB-like factor. It plays a critical role in various steps of transcription initiation, including pre-initiation complex assembly and post-polymerase recruitment events within polymerase I (Pol I) transcription. TAF1B binds to rDNA promoters, contributing to Pol I recruitment as part of the SL1/TIF-IB complex and potentially directly through its interaction with RRN3.

TAF1B is also known as MGC:9349, RAF1B, RAFI63, SL1, TAFI63.

Associated Diseases

WES Whole Exome Sequencing