TAF15
Description
The TAF15 (TATA-box binding protein associated factor 15) is a protein-coding gene located on chromosome 17.
The TAF15 gene in humans codes for the TATA-binding protein-associated factor 2N protein. Transcription initiation by RNA polymerase II requires the coordinated activity of over 70 polypeptides, and TFIID, the central coordinator, binds to the core promoter to position the polymerase correctly, acts as a scaffold for assembling the rest of the transcription complex, and transmits regulatory signals. TFIID consists of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins called TBP-associated factors or TAFs. TAFs may participate in basal transcription, act as coactivators, contribute to promoter recognition, or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF15 is a subunit of TFIID found in a specific subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF resides, result in a gene fusion product that is an RNA-binding protein linked to a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.
TAF15 is an RNA and single-stranded DNA (ssDNA)-binding protein that plays a specific role in transcription initiation at different promoter regions. It can join the preinitiation complex alongside RNA polymerase II (Pol II).
TAF15 is also known as Npl3, RBP56, TAF2N, TAFII68.
