TAF11
Description
The TAF11 (TATA-box binding protein associated factor 11) is a protein-coding gene located on chromosome 6.
TAF11, also known as TAFII28, is a protein encoded by the TAF11 gene in humans. It is a subunit of the Transcription Factor IID (TFIID) complex, which is essential for initiating transcription by RNA polymerase II. TFIID binds to the core promoter to position the polymerase, serves as a scaffold for assembling the transcription complex, and transmits regulatory signals. TAF11 is a small subunit present in all TFIID complexes and interacts with TBP, the TATA-binding protein. It also forms a heterodimer with another small subunit, TAF13, resembling the histone core structure.
The TFIID complex, a key player in RNA polymerase II-dependent transcription, recognizes and binds to promoters, both those with and without TATA boxes, through its TBP subunit. This binding facilitates the assembly of the pre-initiation complex (PIC). TAF11, alongside TAF13 and TBP, plays a crucial role in this promoter binding process, working in conjunction with the TFIIA transcription factor complex.
TAF11 is also known as MGC:15243, PRO2134, TAF2I, TAFII28.
