SYT7
Description
The SYT7 (synaptotagmin 7) is a protein-coding gene located on chromosome 11.
Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene. Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues.
SYT7 is a calcium sensor involved in the release of signaling molecules from cells, primarily through a process called exocytosis. It binds calcium and phospholipids, triggering the fusion of vesicles containing these signaling molecules with the cell membrane, allowing their release. SYT7 is particularly important in synaptic transmission, where it contributes to the rapid and efficient release of neurotransmitters. Additionally, SYT7 plays roles in various cellular processes, including lysosomal exocytosis, which is essential for cell repair and defense against pathogens. SYT7 also facilitates cholesterol transport between organelles, regulates insulin and glucagon secretion, and contributes to the formation of synapses. It interacts with various proteins, including calmodulin and CD63, which help regulate its localization and function.
SYT7 is also known as IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII.
Associated Diseases
- myoepithelial tumor
- autosomal systemic lupus erythematosus type 16
- autosomal recessive limb-girdle muscular dystrophy type 2A
- breast cancer
