SVOP
SVOP Gene: A Comprehensive Overview
Introduction
The SVOP gene, also known as slow virus-associated oncogene homolog (SVOP), plays a crucial role in various cellular processes and is associated with a range of diseases. This gene encodes a protein that is involved in ribosome biogenesis, cell growth, and proliferation. Understanding the SVOP gene is essential for comprehending its impact on health and potential therapeutic implications.
Description
The SVOP gene is located on chromosome 17 in humans. It spans over 100 kilobases and contains 10 exons. The SVOP protein is composed of 419 amino acids and has a molecular weight of approximately 46 kDa. It is highly conserved across species, suggesting its importance in fundamental cellular functions.
Associated Diseases
Mutations or dysregulation of the SVOP gene have been linked to several diseases, including:
- Lung cancer: SVOP mutations are commonly found in non-small cell lung cancer (NSCLC). These mutations can disrupt the protein's function, leading to impaired ribosome biogenesis and uncontrolled cell growth.
- Lymphoma: Mutations in SVOP have been identified in various types of lymphoma, such as diffuse large B-cell lymphoma (DLBCL). These mutations often result in increased expression of the SVOP protein, contributing to tumor development.
- Chromosomal abnormalities: Deletions or amplifications of the SVOP gene locus have been observed in certain chromosomal abnormalities, such as the t(17;19)(q21;p13) translocation in acute myeloid leukemia (AML).
Did you Know ?
Approximately 10% of lung cancer patients harbor SVOP mutations, highlighting the significance of this gene in the development of this malignancy.
