SULT4A1
Description
The SULT4A1 (sulfotransferase family 4A member 1) is a protein-coding gene located on chromosome 22.
Sulfotransferase 4A1 is an enzyme produced by the SULT4A1 gene in humans. It belongs to the sulfotransferase family and is specifically found in the brain. This enzyme is believed to be involved in the metabolism of neurotransmitters. Variations in the SULT4A1 gene have been linked to an increased susceptibility to schizophrenia.
SULT4A1 exhibits unusual characteristics within the sulfotransferase family. It demonstrates weak binding affinity for 3'-phospho-5'-adenylyl sulfate (PAPS), a crucial cofactor in the sulfation process. Additionally, its catalytic activity towards a variety of substrates including L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol is considerably low. Despite these atypical features, SULT4A1 is thought to play a part in the metabolism of drugs and neurotransmitters within the central nervous system (CNS).
SULT4A1 is also known as BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1.
Associated Diseases
- familial infantile myoclonic epilepsy
- infantile convulsions and choreoathetosis
- juvenile myoclonic epilepsy
- spinocerebellar ataxia type 23
- spinocerebellar ataxia type 20
- spinocerebellar ataxia type 15/16
- infantile-onset autosomal recessive nonprogressive cerebellar ataxia
- infantile-onset generalized dyskinesia with orofacial involvement
- urocanic aciduria
- spinocerebellar ataxia type 35
- episodic kinesigenic dyskinesia
- progressive myoclonic epilepsy type 6
- spinocerebellar ataxia type 37
