SULT1A3
Description
The SULT1A3 (sulfotransferase family 1A member 3) is a protein-coding gene located on chromosome 16.
The SULT1A3 gene in humans encodes for the Sulfotransferase 1A3/1A4 enzyme. Sulfotransferases are a family of enzymes that add a sulfate group to various molecules, including hormones, neurotransmitters, drugs, and foreign compounds. These enzymes are located in the cytoplasm of cells and have distinct tissue distributions and substrate preferences. The SULT1A3 gene shares a similar structure with other members of the sulfotransferase family. It encodes a phenol sulfotransferase with heat-sensitive activity. The SULT1A3 gene is located on chromosome 16, close to three other sulfotransferase genes, and is believed to have arisen from a duplication event. This gene is the closest of the four sulfotransferase genes to the centromere. It also overlaps with a gene that encodes a protein containing GIY-YIG domains (GIYD1). Alternative splicing of the SULT1A3 gene results in three variants that produce the same protein.
SULT1A3 is an enzyme that catalyzes the attachment of a sulfate group to various molecules, including phenolic monoamines (like dopamine, norepinephrine, and serotonin), and certain drugs. This process, known as sulfation, is essential for regulating the activity and levels of these molecules.
SULT1A3 is also known as HAST, HAST3, M-PST, ST1A3, ST1A3/ST1A4, ST1A4, ST1A5, STM, TL-PST.
Associated Diseases
- congenital dyserythropoietic anemia type 2
- Senior-Boichis syndrome
- hemolytic anemia due to glucophosphate isomerase deficiency
- progressive familial intrahepatic cholestasis type 3
- non-spherocytic hemolytic anemia due to hexokinase deficiency
- idiopathic hypereosinophilic syndrome
- Crigler-Najjar syndrome type 2
- immunodeficiency 75
- sickle cell anemia
- cholestasis, progressive familial intrahepatic, 9
- pyruvate kinase deficiency of red cells
- intrahepatic cholestasis
- dominant beta-thalassemia
- dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema
