STX10
Description
The STX10 (syntaxin 10) is a protein-coding gene located on chromosome 19.
Syntaxin-10 (STX10) is a SNARE protein encoded by the STX10 gene. It is found in most vertebrates, including humans, but is absent in mice. Like other SNARE proteins, STX10 facilitates vesicle fusion and is essential for intracellular trafficking of proteins and other cellular components. Specifically, STX10 plays a role in endosome-to-Golgi trafficking of the mannose 6-phosphate receptor and glucose transporter type 4. It has been detected in the trans-Golgi network (TGN) by immunofluorescence. Human STX10 is a 249 amino acid protein with three N-terminal α-helices, a single SNARE domain, and a single-pass transmembrane domain. It is 60% identical to human STX6. Structurally, STX10 is classified as a Qc-SNARE, contributing a glutamine (Q) residue to the assembled core SNARE complex. Functionally, it is a t-SNARE, often located in the membranes of target compartments. STX10 interacts with the t-SNAREs VTI1A and STX16, and the v-SNAREs VAMP3 and VAMP4. The SNARE complex of STX10, STX16, VTI1A, and VAMP3 is required for late endosome-to-Golgi trafficking of the mannose 6-phosphate receptor.
STX10 is also known as SYN10, hsyn10.
