STRAP

Description

The STRAP (serine/threonine kinase receptor associated protein) is a protein-coding gene located on chromosome 12.

STRAP (Serine-threonine kinase receptor-associated protein) is an enzyme encoded by the STRAP gene in humans. It interacts with SMAD2, a key member of the SMAD protein family that plays a central role in TGF-beta signaling. SMAD2 is recruited to TGF-beta receptors through its association with the SARA protein, and upon TGF-beta stimulation, it undergoes phosphorylation and dissociates from SARA. This triggers its association with SMAD4 and subsequent translocation into the nucleus, where it acts as a transcription repressor. The interaction between STRAP and SMAD2 is crucial for regulating cellular processes like proliferation, apoptosis, and differentiation.

STRAP, also known as MAP activator with WD repeats (MAWBP), UNR-interacting protein (UNRIP), and WD-40 repeat protein PT-WD, is a crucial component of the SMN complex. This complex plays a vital role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential for splicing cellular pre-mRNAs. The SMN complex acts as a chaperone, accepting trapped Sm proteins from CLNS1A and facilitating their assembly into the core snRNP. STRAP contributes to the proper cellular distribution of the SMN complex, influencing its localization within the cell. Beyond its role in splicing, STRAP also influences signaling pathways. It negatively regulates TGF-beta signaling, while positively regulating PDPK1 kinase activity by enhancing its autophosphorylation and reducing its association with 14-3-3 protein.

STRAP is also known as MAWD, PT-WD, UNRIP.

Associated Diseases

WES Whole Exome Sequencing