STK26
Description
The STK26 (serine/threonine kinase 26) is a protein-coding gene located on chromosome X.
STK26, also known as MST3 and SOK1-related kinase, plays a role in regulating cell growth and apoptosis. It interacts with STK24 to negatively regulate Golgi reorientation during polarized cell migration. STK26 also phosphorylates ATG4B, increasing autophagic flux.
STK26 is also known as MASK, MST4.
Associated Diseases
- ovarian cancer
- endometrial cancer
- cancer
- retinoblastoma
- thyroid cancer, nonmedullary, 1
- goiter, multinodular 1, with or without Sertoli-Leydig cell tumors
- hypothyroidism due to TSH receptor mutations
- glycogen storage disease due to glycogen branching enzyme deficiency
- thyrocerebrorenal syndrome
- hypothyroidism, congenital, nongoitrous
- hypothyroidism, congenital, nongoitrous, 5
- thyroid cancer, nonmedullary, 4
- hereditary chronic pancreatitis
- Pendred syndrome
