STK24
Description
The STK24 (serine/threonine kinase 24) is a protein-coding gene located on chromosome 13.
STK24 (Serine/threonine-protein kinase 24) is an enzyme encoded by the STK24 gene located on chromosome 13, band q32.2. It is also known as Mammalian STE20-like protein kinase 3 (MST-3). The protein is 443 amino acids long and has a mass of 49 kDa. STK24 belongs to the GCK subfamily of STE20-like kinases, which are related to the yeast 'Sterile 20' gene (STE20) that functions upstream of the mitogen-activated protein kinase (MAPK) cascade. Members of the GCK subfamily have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain.
STK24 is a serine/threonine-protein kinase that promotes apoptosis in response to stress stimuli and caspase activation. It mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. STK24 plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. It phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26, STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. STK24 regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: it phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. STK24 may act as a key regulator of axon regeneration in the optic nerve and radial nerve.
STK24 is also known as HEL-S-95, MST3, MST3B, STE20, STK3.
