STK16
Description
The STK16 (serine/threonine kinase 16) is a protein-coding gene located on chromosome 2.
STK16 is an enzyme that in humans is encoded by the STK16 gene. It is involved in the phosphorylation of proteins, a process that regulates their activity and function.
STK16 is a membrane-associated protein kinase that phosphorylates serine and threonine residues on various substrates, including DRG1, ENO1, and EIF4EBP1. It also autophosphorylates, potentially playing a role in secretory vesicle trafficking, intracellular signaling, and regulation of stromal-epithelial interactions during mammary ductal morphogenesis. STK16 might be involved in TGF-beta signaling and exhibits autophosphorylation on tyrosine residues, though its tyrosine kinase activity towards other proteins remains unclear.
STK16 is also known as KRCT, MPSK, PKL12, PSK, TSF1, hPSK.
Associated Diseases
- cancer
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hemoglobin D disease
- gamma-glutamylcysteine synthetase deficiency
- delta-beta-thalassemia
- hemoglobin E-beta-thalassemia syndrome
- alpha thalassemia-intellectual disability syndrome type 1
- alpha-thalassemia-myelodysplastic syndrome
- hemoglobin C-beta-thalassemia syndrome
- dominant beta-thalassemia
