STEAP4

Description

The STEAP4 (STEAP4 metalloreductase) is a protein-coding gene located on chromosome 7.

STEAP4 is a protein encoded by the STEAP4 gene in humans. It belongs to the STEAP (six transmembrane epithelial antigen of prostate) family and resides in the Golgi apparatus. STEAP4 functions as a metalloreductase, capable of reducing both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) using NAD(+) as an acceptor. Research in mice and humans suggests that STEAP4 may be involved in adipocyte development and metabolism. It may also contribute to the normal biology of prostate cells and prostate cancer progression. Different isoforms of STEAP4 are produced through alternative splicing.

STEAP4 is an integral membrane protein that acts as a NADPH-dependent ferric-chelate reductase, utilizing NADPH from one side of the membrane to reduce a Fe(3+) chelate bound on the opposite side. This process involves sequential transmembrane electron transfer from NADPH to FAD, then to heme, and finally to the Fe(3+) chelate. STEAP4 also exhibits the ability to reduce Cu(2+) to Cu(1+). It plays a crucial role in systemic metabolic homeostasis by integrating inflammatory and metabolic responses. Studies have linked STEAP4 to obesity and insulin resistance. Additionally, it is implicated in inflammatory arthritis through the regulation of inflammatory cytokines. STEAP4 has been shown to inhibit anchorage-independent cell proliferation. It forms a homotrimer and interacts with PTK2/FAK1, potentially regulating PTK2 phosphorylation.

STEAP4 is also known as STAMP2, SchLAH, TIARP, TNFAIP9.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing