STEAP2

Description

The STEAP2 (STEAP2 metalloreductase) is a protein-coding gene located on chromosome 7.

STEAP2 is an enzyme encoded by the STEAP2 gene in humans. It is a member of the STEAP family and is a multi-pass membrane protein found in the Golgi complex, the plasma membrane, and vesicular tubular structures in the cytosol. A similar protein in mice has both ferri reductase and cupric reductase activity, and stimulates cellular uptake of both iron and copper in vitro. Increased expression of the human STEAP2 gene is linked to prostate cancer progression. Different isoforms of the protein are produced from alternate transcriptional splice variants.

STEAP2 is an integral membrane protein that acts as a NADPH-dependent ferric-chelate reductase. It uses NADPH from one side of the membrane to reduce a Fe(3+) chelate bound on the other side. This process involves sequential transmembrane electron transfer, starting with NADPH, then to FAD, then heme, and finally to the Fe(3+) chelate. STEAP2 can also reduce Cu(2+) to Cu(1+).

STEAP2 is also known as IPCA1, PCANAP1, PUMPCn, STAMP1, STMP.

Associated Diseases

WES Whole Exome Sequencing