STAU2
Description
The STAU2 (staufen double-stranded RNA binding protein 2) is a protein-coding gene located on chromosome 8.
STAU2, encoded by the STAU2 gene, is a double-stranded RNA (dsRNA)-binding protein that plays a role in the transport and localization of mRNAs within cells. These proteins, including STAU2, are characterized by their multiple dsRNA-binding domains, essential for binding to RNAs with double-stranded secondary structures. STAU2 shares similarities with its counterparts in Drosophila and humans, namely Staufen. While its exact function remains under investigation, its three conserved dsRNA binding domains suggest a role in double-stranded RNA binding events. Research indicates that the expression of Stau2 can increase eye size, suggesting a novel biological function in eye morphogenesis.
STAU2 is a crucial RNA-binding protein involved in the transport of neuronal RNA from the cell body to the dendrite. This movement is dependent on microtubules, and it's thought to be essential for neurite outgrowth and plasticity, as protein synthesis occurs within the dendrite, requiring the delivery of specific mRNAs.
STAU2 is also known as 39K2, 39K3.
Associated Diseases
- type 2 diabetes mellitus
- hemoglobin D disease
- primary familial polycythemia due to EPO receptor mutation
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- X-linked sideroblastic anemia 1
- dominant beta-thalassemia
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- delta-beta-thalassemia
