STAT3 : signal transducer and activator of transcription 3
Description
The STAT3 gene encodes a transcription factor, STAT3 protein, which plays a critical role in cell growth, differentiation, and survival. It is activated by various signaling pathways, including those involving cytokines, growth factors, and hormones. Upon activation, STAT3 translocates to the nucleus and regulates the expression of target genes involved in cellular processes such as proliferation, apoptosis, and immune responses.
Associated Diseases
- Cancer (e.g., leukemia, breast cancer, lung cancer)
- Inflammatory diseases (e.g., rheumatoid arthritis, Crohn‘s disease)
- Autoimmune disorders (e.g., lupus)
- Neurological disorders (e.g., Alzheimer‘s disease)
- Cardiovascular diseases
Did you know?
STAT3 is a key player in the development of drug resistance in cancer cells.
