STAM

Description

The STAM (signal transducing adaptor molecule) is a protein-coding gene located on chromosome 10.

STAM can refer to: Signal transducing adapter molecule 1 (STAM-1) Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. (Microbial infection) Plays an important role in Dengue virus entry. Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:11687594, PubMed:19278655, PubMed:9407053). Probably part of a complex at least composed of HSG, STAM and EPS15 (PubMed:12551915). Found in a complex with HGS and E3 ligase ITCH and DTX3L (PubMed:24790097). Interacts with E3 ligase DTX3L; the interaction brings together STAM and HSG, promotes their recruitment to early endosomes and decreases STAM and HGS ubiquitination by ITCH (PubMed:24790097). Interacts with STAMBP/AMSH (PubMed:10383417). Interacts with PDGFRB (PubMed:20494825). Interacts with LITAF; the interaction is direct (PubMed:23166352). Identified in a complex with HGS and LITAF (PubMed:23166352). Interacts with HAVCR1 (PubMed:29742433).

STAM plays a crucial role in intracellular signaling pathways triggered by cytokines and growth factors. Upon stimulation by IL-2 and GM-CSF, it participates in signaling cascades leading to DNA synthesis and the activation of the MYC gene. STAM may also contribute to T-cell development. In conjunction with HGS, forming the ESCRT-0 complex, STAM is involved in the downregulation of receptor tyrosine kinases through the multivesicular body (MVB) pathway. The ESCRT-0 complex specifically binds ubiquitin, acting as a sorting mechanism that identifies ubiquitinated receptors and directs them towards subsequent lysosomal sorting and trafficking processes.

STAM is also known as STAM-1, STAM1.

Associated Diseases

WES Whole Exome Sequencing