ST8SIA6
Description
The ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6) is a protein-coding gene located on chromosome 10.
ST8SIA6 is a human gene encoding the ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 protein. Sialic acid plays a crucial role in various cellular processes, including communication, interaction with substrates, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases that synthesize sialylglycoconjugates, complex sugar molecules essential for these cellular functions.
ST8SIA6 is an alpha-2,8-sialyltransferase that preferentially catalyzes the transfer of sialic acid to O-glycans, compared to N-glycans or glycolipids. It specifically targets the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of carbohydrate chains.
ST8SIA6 is also known as SIA8F, SIAT8-F, SIAT8F, ST8SIA-VI, ST8SiaVI.
Associated Diseases
- prostate cancer
- neutropenia, severe congenital, 9, autosomal dominant
- galactosemia 4
- aniridia
- megalocornea
- isolated ectopia lentis
