ST6GALNAC6
Description
The ST6GALNAC6 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6) is a protein-coding gene located on chromosome 9.
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.
ST6GALNAC6, also known as GalNAc alpha-2,6-sialyltransferase VI, ST6GalNAc VI, or Sialyltransferase 7F, transfers a sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to glycoproteins and glycolipids, forming an alpha-2,6-linkage. This enzyme produces branched type disialyl structures by transferring a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI exhibits a preference for glycolipids over glycoproteins, primarily catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). In addition to GMb1, MSGG, and other glycolipids, it shows activity toward sialyl Lc4Cer, generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), proposed to be a cancer-associated antigen (PubMed:12668675). This enzyme also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). {ECO:0000250|UniProtKB:Q9JM95, ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}
ST6GALNAC6 is also known as SIAT7-F, SIAT7F, ST6GALNACVI.
