ST6GALNAC5
Description
The ST6GALNAC5 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) is a protein-coding gene located on chromosome 1.
ST6GALNAC5, also known as GD1 alpha synthase, catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain. This enzyme transfers a sialyl group from CMP-NeuAc to the GalNAc residue on the GM1b molecule. GD1alpha plays a crucial role in neuronal cell communication and interaction, particularly in brain tissues, and acts as an adhesion molecule during metastasis. ST6GALNAC5 also exhibits activity towards sialyl Lc4Cer, generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), a potential cancer-associated antigen.
ST6GALNAC5 is also known as SIAT7-E, SIAT7E, ST6GalNAcV.
