ST6GALNAC4
Description
The ST6GALNAC4 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4) is a protein-coding gene located on chromosome 9.
ST6GALNAC4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D), is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene. It's a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins over glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. Additionally, it's involved in the synthesis of ganglioside GD1A from GM1B. The enzyme is normally found in the Golgi apparatus but can be proteolytically processed into a soluble form. This protein belongs to glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene.
ST6GALNAC4 is also known as IV, SIAT3-C, SIAT3C, SIAT7-D, SIAT7D, ST6GALNACIV, ST6GalNAc.
