SSX2IP

Description

The SSX2IP (SSX family member 2 interacting protein) is a protein-coding gene located on chromosome 1.

SSX2IP is a protein that in humans is encoded by the SSX2IP gene. It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation. The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis. SSX2IP has been initially described as a protein to interact with MLLT4 and Actinin, alpha 1. In the context of centrosome maturation and ciliogenesis it has been shown to interact with WDR8.

SSX2IP is involved in the organization of cell-cell adherens junctions (AJs) by connecting the nectin-afadin and E-cadherin-catenin systems through alpha-actinin. It also plays a role in organizing the actin cytoskeleton at AJs through afadin and alpha-actinin. Additionally, SSX2IP is involved in cell movement, localizing at the leading edge of moving cells in response to PDGF. It is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling. SSX2IP acts as a centrosome maturation factor, maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The SSX2IP:WRAP73 complex acts as a regulator of spindle anchoring at the mitotic centrosome. SSX2IP is also involved in ciliogenesis, being required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia.

SSX2IP is also known as ADIP, hMsd1.

Associated Diseases

WES Whole Exome Sequencing