SSX2
Description
The SSX2 (SSX family member 2) is a protein-coding gene located on chromosome X.
The SSX2 gene encodes a protein that belongs to the SSX family, which are highly similar synovial sarcoma, X breakpoint proteins. These proteins might act as transcriptional repressors. They can trigger immune responses in cancer patients, making them potential targets for cancer immunotherapy. SSX1, SSX2, and SSX4 genes are involved in the t(X;18) translocation found in all synovial sarcomas. This translocation fuses the synovial sarcoma translocation gene on chromosome 18 with one of the SSX genes on chromosome X. The resulting hybrid proteins likely cause transforming activity. Two transcript variants encoding different isoforms have been found for this gene.
This protein potentially acts as a transcriptional modulator.
SSX2 is also known as CT5.2, CT5.2A, HD21, HOM-MEL-40, SSX.
