SSTR5

The SSTR5 Gene: A Gateway to Unlocking Health

Description:

The SSTR5 gene, located on chromosome 11, encodes the somatostatin receptor subtype 5 (SSTR5). This receptor is a member of the G protein-coupled receptor (GPCR) superfamily and plays a crucial role in regulating various physiological processes, including growth, metabolism, and neurotransmission.

Associated Diseases:

Mutations in the SSTR5 gene have been linked to several diseases, including:

• Acromegaly: A condition characterized by overgrowth of the hands, feet, and face due to excessive growth hormone secretion.
• Carcinoid tumors: Neuroendocrine tumors that often secrete serotonin and other hormones.
• Neuroendocrine pancreatic tumors (NETs): A group of rare tumors that originate in the endocrine cells of the pancreas.
• Pituitary tumors: Benign or malignant tumors that develop in the pituitary gland.
• Type 2 diabetes: A chronic metabolic disorder characterized by insulin resistance and elevated blood sugar levels.

Did you Know ?

Studies estimate that mutations in the SSTR5 gene account for approximately 10% of cases of acromegaly, a rare condition affecting about 4 out of every 1 million people worldwide.