SST
The SST Gene: Unraveling Its Role in Health and Disease
Introduction
Nestled within our genetic code lies the somatostatin (SST) gene, a pivotal player in regulating a myriad of physiological processes. Its primary role is to produce the hormone somatostatin, a key regulator of hormone secretion, cell growth, and immune function. In this comprehensive blog post, we will explore the multifaceted world of the SST gene, delving into its functions, associated diseases, and the latest research advancements.
Description
The SST gene resides on chromosome 3 of the human genome. It encodes for the preprosomatostatin protein, which undergoes subsequent processing to release somatostatin. Somatostatin exists in two primary isoforms: SST-14 and SST-28. Both isoforms inhibit the secretion of various hormones, including growth hormone, thyroid-stimulating hormone (TSH), and insulin.
Associated Diseases
Mutations or variations in the SST gene have been linked to several diseases, including:
- Acromegaly: A rare disorder characterized by excessive growth hormone secretion, leading to enlarged hands, feet, and facial features.
- Neuroendocrine tumors: Tumors that originate from cells that produce hormones and other signaling molecules. These tumors can arise in various organs, such as the pancreas, stomach, and lungs.
- Diabetes insipidus: A condition characterized by excessive thirst and urine production due to impaired antidiuretic hormone (ADH) secretion.
- Pituitary adenomas: Non-cancerous growths in the pituitary gland, which secretes a variety of hormones.
Did you Know ?
Approximately 1 in 1,000 people worldwide are affected by acromegaly, highlighting the prevalence of diseases associated with SST gene mutations.
