SREBF2
Description
The SREBF2 (sterol regulatory element binding transcription factor 2) is a protein-coding gene located on chromosome 22.
SREBF2 is a gene that encodes a protein involved in cholesterol homeostasis. This protein is a transcription factor that activates the expression of genes involved in cholesterol biosynthesis. It has a basic helix-loop-helix leucine zipper (bHLH-Zip) domain and interacts with INSIG1 and CREB-binding protein. Certain SNPs in the SREBF2 gene are associated with an increased risk of knee osteoarthritis.
SREBP2 is a precursor protein embedded in the endoplasmic reticulum membrane. When cholesterol levels are low, SREBP2 is processed and released as a transcription factor that moves to the nucleus. There, it activates genes involved in cholesterol synthesis, helping to increase cholesterol production.
SREBF2 is also known as SREBP-2, SREBP2, bHLHd2.
