SPSB1
Description
The SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) is a protein-coding gene located on chromosome 1.
SPRY domain-containing SOCS box protein 1 is a protein that in humans is encoded by the SPSB1 gene.
SPSB1 is a substrate recognition component of an E3 ubiquitin ligase complex called ECS (Elongin BC-CUL2/5-SOCS-box protein). This complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins. SPSB1 plays a crucial role in regulating nitric oxide (NO) production by promoting the degradation of NOS2, an enzyme involved in NO synthesis. This degradation limits cellular toxicity in activated macrophages. SPSB1 acts as a bridge connecting NOS2 to the ECS complex components ELOC and CUL5, facilitating the ubiquitination process.
SPSB1 is also known as SSB-1, SSB1.
